Ontology highlight
ABSTRACT:
SUBMITTER: Korecka JA
PROVIDER: S-EPMC6335600 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Korecka Joanna A JA Talbot Sebastien S Osborn Teresia M TM de Leeuw Sherida M SM Levy Simon A SA Ferrari Eliza J EJ Moskites Alyssa A Atkinson Elise E Jodelka Francine M FM Hinrich Anthony J AJ Hastings Michelle L ML Woolf Clifford J CJ Hallett Penelope J PJ Isacson Ole O
Stem cell reports 20181227 1
The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S mutation exhibited neurite collapse when challenged with the ER Ca<sup>2+</sup> influx sarco/ER Ca<sup>2+</sup>-ATPase inhibitor thapsigargin (THP). Baseline ER Ca<sup>2+</sup> levels measured with the ER Ca<sup>2+</sup> indicator CEPIA-ER were lower in LRRK2 ...[more]