Ontology highlight
ABSTRACT:
SUBMITTER: Jiang M
PROVIDER: S-EPMC6336687 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Jiang Mingzuo M Xu Bing B Li Xiaowei X Shang Yulong Y Chu Yi Y Wang Weijie W Chen Di D Wu Nan N Hu Sijun S Zhang Song S Li Mengbin M Wu Kaichun K Yang Xiaoyong X Liang Jie J Nie Yongzhan Y Fan Daiming D
Oncogene 20180809 3
Advanced colorectal cancer (CRC) is one of the deadliest cancers, and the 5-year survival rate of patients with metastasis is extremely low. The epithelial-mesenchymal transition (EMT) is considered essential for metastatic CRC, but the fundamental molecular basis underlying this effect remains unknown. Here, we identified that O-GlcNAcylation, a unique posttranslational modification (PTM) involved in cancer metabolic reprogramming, increased the metastatic capability of CRC. The levels of O-Glc ...[more]