Ontology highlight
ABSTRACT:
SUBMITTER: Jappinen N
PROVIDER: S-EPMC6336770 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Jäppinen Norma N Félix Inês I Lokka Emmi E Tyystjärvi Sofia S Pynttäri Anne A Lahtela Tiina T Gerke Heidi H Elima Kati K Rantakari Pia P Salmi Marko M
Nature communications 20190117 1
Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resident mammary gland macrophages using high-dimension phenotypic analyses, cell-fate mapping experiments, gene-deficient mice lacking selective macrophage subtypes, and antibody-based ...[more]