Ontology highlight
ABSTRACT:
SUBMITTER: Moreira J
PROVIDER: S-EPMC6337158 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Moreira Joana J Ribeiro Diana D Silva Patrícia M A PMA Nazareth Nair N Monteiro Madalena M Palmeira Andreia A Saraiva Lucília L Pinto Madalena M Bousbaa Hassan H Cidade Honorina H
Molecules (Basel, Switzerland) 20181231 1
The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7 activity. The synthesis of twenty-five flavonoids (<b>4</b>⁻<b>28</b>) with one or more alkyl side chains was carried out. The synthetic approach was based on the reaction with alkyl halide in alkaline medium by microwave (MW) irradiation. The in vi ...[more]