Ontology highlight
ABSTRACT:
SUBMITTER: Piasny J
PROVIDER: S-EPMC7321363 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Piasny Janusz J Wiatrak Benita B Dobosz Agnieszka A Tylińska Beata B Gębarowski Tomasz T
Molecules (Basel, Switzerland) 20200528 11
Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, <i>Aspidosperma olivaceum.</i> Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic and fully synthetic pyridocarbazoles. This study aimed to evaluate the potential antineoplastic activity of four newly synthesized olivacine derivatives. Multidrug resistance is a common phenomenon causing failure in the chemotherapy of many ...[more]