Ontology highlight
ABSTRACT:
SUBMITTER: Chen KT
PROVIDER: S-EPMC6337199 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Chen Kuo-Ting KT Nguyen Kevin K Ieritano Christian C Gao Feng F Seimbille Yann Y
Molecules (Basel, Switzerland) 20181221 1
We herein describe a flexible synthesis of a small library of <sup>68</sup>Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol click reaction. Three novel CBT-functionalized chelators (<b>1</b>⁻<b>3</b>) were successfully synthesized and labeled with the positron emitter gallium-68. Cross-ligation between the pre-labeled bifunctional chelators (BFCs) and the 1,2-aminothiol-acetazolamide derivatives (<b>8</b> and <b>9</b>) yielded six new <sup>68</sup>Ga ...[more]