Ontology highlight
ABSTRACT:
SUBMITTER: Van Kersavond T
PROVIDER: S-EPMC6337261 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190108 1
Chemical probes that covalently interact with proteases have found increasing use for the study of protease function and localization. The design and synthesis of such probes is still a bottleneck, as the strategies to target different families are highly diverse. We set out to design and synthesize chemical probes based on protease substrate specificity with inclusion of an uncleavable peptide bond mimic and a photocrosslinker for covalent modification of the protease target. With caspase-3 as ...[more]