Ontology highlight
ABSTRACT:
SUBMITTER: Wauters L
PROVIDER: S-EPMC6337361 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Wauters Lina L Versées Wim W Kortholt Arjan A
International journal of molecular sciences 20190103 1
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of genetically inherited Parkinson's Disease (PD). LRRK2 is a large, multi-domain protein belonging to the Roco protein family, a family of GTPases characterized by a central RocCOR (Ras of complex proteins/C-terminal of Roc) domain tandem. Despite the progress in characterizing the GTPase function of Roco proteins, there is still an ongoing debate concerning the working mechanism of Roco proteins in general, and LRRK2 in parti ...[more]