Ontology highlight
ABSTRACT:
SUBMITTER: Yanagida K
PROVIDER: S-EPMC6338314 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Yanagida Keisuke K Igarashi Hidemitsu H Yasuda Daisuke D Kobayashi Daiki D Ohto-Nakanishi Takayo T Akahoshi Noriyuki N Sekiba Atsushi A Toyoda Tsudoi T Ishijima Tomoko T Nakai Yuji Y Shojima Nobuhiro N Kubota Naoto N Abe Keiko K Kadowaki Takashi T Ishii Satoshi S Shimizu Takao T
JCI insight 20181220 24
White adipose tissue (WAT) can dynamically expand and remodel through adipocyte hypertrophy and hyperplasia. The relative contribution of these 2 mechanisms to WAT expansion is a critical determinant of WAT function and dysfunction in obesity. However, little is known about the signaling systems that determine the mechanisms of WAT expansion. Here, we show that the GPCR LPA4 selectively activates Gα12/13 proteins in adipocytes and limits continuous remodeling and healthy expansion of WAT. LPA4-K ...[more]