Ontology highlight
ABSTRACT:
SUBMITTER: Wen XY
PROVIDER: S-EPMC6338320 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wen Xiao-Yan XY Tarailo-Graovac Maja M Brand-Arzamendi Koroboshka K Willems Anke A Rakic Bojana B Huijben Karin K Da Silva Afitz A Pan Xuefang X El-Rass Suzan S Ng Robin R Selby Katheryn K Philip Anju Mary AM Yun Junghwa J Ye X Cynthia XC Ross Colin J CJ Lehman Anna M AM Zijlstra Fokje F Abu Bakar N N Drögemöller Britt B Moreland Jacqueline J Wasserman Wyeth W WW Vallance Hilary H van Scherpenzeel Monique M Karbassi Farhad F Hoskings Martin M Engelke Udo U de Brouwer Arjan A Wevers Ron A RA Pshezhetsky Alexey V AV van Karnebeek Clara Dm CD Lefeber Dirk J DJ
JCI insight 20181220 24
Sialic acids are important components of glycoproteins and glycolipids essential for cellular communication, infection, and metastasis. The importance of sialic acid biosynthesis in human physiology is well illustrated by the severe metabolic disorders in this pathway. However, the biological role of sialic acid catabolism in humans remains unclear. Here, we present evidence that sialic acid catabolism is important for heart and skeletal muscle function and development in humans and zebrafish. I ...[more]