Immune genes are hotspots of shared positive selection across birds and mammals.
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ABSTRACT:
SUBMITTER: Shultz AJ
PROVIDER: S-EPMC6338464 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Immune genes are hotspots of shared positive selection across birds and mammals.
Shultz Allison J AJ Sackton Timothy B TB
eLife 20190108
Consistent patterns of positive selection in functionally similar genes can suggest a common selective pressure across a group of species. We use alignments of orthologous protein-coding genes from 39 species of birds to estimate parameters related to positive selection for 11,000 genes conserved across birds. We show that functional pathways related to the immune system, recombination, lipid metabolism, and phototransduction are enriched for positively selected genes. By comparing our results w ...[more]
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