Ontology highlight
ABSTRACT:
SUBMITTER: Jukic M
PROVIDER: S-EPMC6339874 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Jukič Marko M Rožman Kaja K Sova Matej M Barreteau Hélène H Gobec Stanislav S
Frontiers in microbiology 20190114
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from <i>Escherichia coli.</i> UppS is an essential enzyme in the biosynthesis of bacterial cell wall. It catalyzes the condensation of farnesyl pyrophosphate (FPP) with eight consecutive isopentenyl pyrophosphate units (IPP), in which new <i>cis</i>-double bonds are formed, to generate undecaprenyl pyrophosphate. The latter serves as a lipid carrier for pe ...[more]