Ontology highlight
ABSTRACT:
SUBMITTER: Ko TP
PROVIDER: S-EPMC6277960 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Ko Tzu Ping TP Huang Chi Hung CH Lai Shu Jung SJ Chen Yeh Y
Acta crystallographica. Section F, Structural biology communications 20181116 Pt 12
Undecaprenyl pyrophosphate (UPP) is an important carrier of the oligosaccharide component in peptidoglycan synthesis. Inhibition of UPP synthase (UPPS) may be an effective strategy in combating the pathogen Acinetobacter baumannii, which has evolved to be multidrug-resistant. Here, A. baumannii UPPS (AbUPPS) was cloned, expressed, purified and crystallized, and its structure was determined by X-ray diffraction. Each chain of the dimeric protein folds into a central β-sheet with several surroundi ...[more]