Ontology highlight
ABSTRACT:
SUBMITTER: Lundberg R
PROVIDER: S-EPMC6893776 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Lundberg Rickard R Melén Krister K Westenius Veera V Jiang Miao M Österlund Pamela P Khan Hira H Vapalahti Olli O Julkunen Ilkka I Kakkola Laura L
Viruses 20191104 11
The Zika virus (ZIKV) is a member of the <i>Flaviviridae</i> family and an important human pathogen. Most pathogenic viruses encode proteins that interfere with the activation of host innate immune responses. Like other flaviviruses, ZIKV interferes with the expression of interferon (IFN) genes and inhibits IFN-induced antiviral responses. ZIKV infects through epithelial barriers where IFN-λ1 is an important antiviral molecule. In this study, we analyzed the effects of ZIKV proteins on the activ ...[more]