Ontology highlight
ABSTRACT:
SUBMITTER: Aran D
PROVIDER: S-EPMC6340744 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Aran Dvir D Looney Agnieszka P AP Liu Leqian L Wu Esther E Fong Valerie V Hsu Austin A Chak Suzanna S Naikawadi Ram P RP Wolters Paul J PJ Abate Adam R AR Butte Atul J AJ Bhattacharya Mallar M
Nature immunology 20190114 2
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific subgroups in supporting fibrogenesis has not been investigated in vivo. Here, we used single-cell RNA sequencing (scRNA-seq) to characterize the heterogeneity of macrophages in bleomycin-induced lung fibrosis in mice. A novel computational framework for the annotation of scRNA-seq by reference to bulk transcript ...[more]