Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs DI
PROVIDER: S-EPMC6340885 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Jacobs Daniel I DI Qin Qin Q Fu Alan A Chen Zeming Z Zhou Jiangbing J Zhu Yong Y
Oncotarget 20181228 102
PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that partner with PIWI proteins to protect germline tissues from destabilizing transposon activity. While the aberrant expression of PIWI proteins has been linked with poor outcomes for many cancers, less is known about the expression or function of piRNAs in cancer. We performed array-based piRNA expression profiling in seven pairs of normal brain and glioblastoma multiforme (GBM) tissue specimens, and identified expression of ~350 piRNAs ...[more]