Ontology highlight
ABSTRACT:
SUBMITTER: Escamilla-Tilch M
PROVIDER: S-EPMC6341406 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Escamilla-Tilch Mónica M Pérez-Suárez Thalía Gabriela TG Torres-Carrillo Nora Magdalena NM Rodríguez-Guillén Rosario R Arenas-Guzmán Roberto R Torres-Hernández Marcela M Fafutis-Morris Mary M Estrada-Parra Sergio S Estrada-Garía Iris I García-Lechuga Maricela M Granados Julio J Ramos-Payan Rosalio R
Biomedical reports 20190107 2
Leprosy, a human chronic granulomatous disease caused by <i>Mycobacterium leprae (M. leprae)</i>, remains endemic in certain countries despite the use of multidrug therapy. Recently, several host genes modulating the immune responses to <i>M. leprae</i> infection have been suggested to influence the acquisition and clinical course of leprosy. Lymphoid protein tyrosine phosphatase, encoded by the protein tyrosine phosphatase non-receptor type 22 (<i>PTPN22</i>) gene, serves a negative regulatory ...[more]