Ontology highlight
ABSTRACT:
SUBMITTER: Kou KGM
PROVIDER: S-EPMC6342194 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20180619 26
The hetisine-type natural products exhibit one of the most complex carbon skeletons within the diterpenoid alkaloid family. The use of network analysis has enabled a synthesis strategy to access alkaloids in this class with hydroxylation on the A-ring. Key transformations include a benzyne acyl-alkylation to construct a key fused 6-7-6 tricycle, a chemoselective nitrile reduction, and sequential C-N bond formations using a reductive cyclization and a photochemical hydroamination to construct an ...[more]