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Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression.

ABSTRACT: Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC50 values while not inducing mitochondrial toxicity at 12.5 ?M.

SUBMITTER: El-Elimat T

PROVIDER: S-EPMC6343109 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression.

El-Elimat Tamam T Raja Huzefa A HA Ayers Sloan S Kurina Steven J SJ Burdette Joanna E JE Mattes Zachary Z Sabatelle Robert R Bacon Jeffrey W JW Colby Aaron H AH Grinstaff Mark W MW Pearce Cedric J CJ Oberlies Nicholas H NH

Organic letters 20190108 2

Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC50 values while not inducing mitochondrial toxicity at 12.5 μM. ...[more]

PMID: 30620608

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