Ontology highlight
ABSTRACT:
SUBMITTER: Rampoldi A
PROVIDER: S-EPMC6343126 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Rampoldi Antonio A Crooke Stephen N SN Preininger Marcela K MK Jha Rajneesh R Maxwell Joshua J Ding Lingmei L Spearman Paul P Finn M G MG Xu Chunhui C
ACS chemical biology 20180719 8
Sensitization to prodrugs via transgenic expression of suicide genes is a leading strategy for the selective elimination of potentially tumorigenic human pluripotent stem cells (hPSCs) in regenerative medicine, but transgenic modification poses safety risks such as deleterious mutagenesis. We describe here an alternative method of delivering suicide-inducing molecules explicitly to hPSCs using virus-like particles (VLPs) and demonstrate its use in eliminating undifferentiated hPSCs in vitro. VLP ...[more]