Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi T
PROVIDER: S-EPMC4291089 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Kobayashi Toshihiro T Kato-Itoh Megumi M Nakauchi Hiromitsu H
Stem cells and development 20150101 2
Generation of functional organs from patients' own cells is one of the ultimate goals of regenerative medicine. As a novel approach to creation of organs from pluripotent stem cells (PSCs), we employed blastocyst complementation in organogenesis-disabled animals and successfully generated PSC-derived pancreas and kidneys. Blastocyst complementation, which exploits the capacity of PSCs to participate in forming chimeras, does not, however, exclude contribution of PSCs to the development of tissue ...[more]