Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Edler MK
PROVIDER: S-EPMC6343147 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease.
Edler Melissa K MK Sherwood Chet C CC Meindl Richard S RS Hopkins William D WD Ely John J JJ Erwin Joseph M JM Mufson Elliott J EJ Hof Patrick R PR Raghanti Mary Ann MA
Neurobiology of aging 20170801
Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20, age 37-62 years) for evidence of Aβ and tau lesions in brain regions affected by AD in humans. Aβ was observed in plaques and blood vessels, and tau lesions were found in the form ...[more]
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