Ontology highlight
ABSTRACT:
SUBMITTER: Veale DJ
PROVIDER: S-EPMC6343466 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Veale Douglas J DJ McGonagle Dennis D McInnes Iain B IB Krueger James G JG Ritchlin Christopher T CT Elewaut Dirk D Kanik Keith S KS Hendrikx Thijs T Berstein Gabriel G Hodge Jennifer J Telliez Jean-Baptiste JB
Rheumatology (Oxford, England) 20190201 2
The pathogenesis of SpA is multifactorial and involves a range of immune cell types and cytokines, many of which utilize Janus kinase (JAK) pathways for signaling. In this review, we summarize the animal and pre-clinical data that have demonstrated the effects of JAK blockade on the underlying molecular mechanisms of SpA and provide a rationale for JAK inhibition for the treatment of SpA. We also review the available clinical trial data evaluating JAK inhibitors tofacitinib, baricitinib, peficit ...[more]