Ontology highlight
ABSTRACT:
SUBMITTER: Deng K
PROVIDER: S-EPMC6343689 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Deng Ke K Shen Jiawei J Wang Wei W Li Ming M Li Hong H Chen Cheng C Zhao Huan H Zhang Mei M Xue Tian T Liu Qingsong Q Lui Vivian Wai Yan VWY Hong Bo B Lin Wenchu W
Cancer biology & therapy 20180905 1
Small cell lung cancer (SCLC) is a malignant neuroendocrine tumor with very high mortality. Effective new therapy for advanced SCLC patients is urgently needed. By screening a FDA-approved drug library, we identified a cardiac glycoside (CG), namely digoxin (an inhibitor of cellular Na<sup>+</sup>/K<sup>+</sup> ATPase pump), which was highly effective in inhibiting SCLC cell growth. Intriguing findings showed that NaCl supplement markedly enhanced the anti-tumor activities of digoxin in both in ...[more]