Ontology highlight
ABSTRACT:
SUBMITTER: Vasjari L
PROVIDER: S-EPMC6343710 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Vasjari Ledia L Bresan Stephanie S Biskup Christoph C Pai Govind G Rubio Ignacio I
Cell cycle (Georgetown, Tex.) 20190102 2
Numerous studies exploring oncogenic Ras or manipulating physiological Ras signalling have established an irrefutable role for Ras as driver of cell cycle progression. Despite this wealth of information the precise signalling timeline and effectors engaged by Ras, particularly during G1, remain obscure as approaches for Ras inhibition are slow-acting and ill-suited for charting discrete Ras signalling episodes along the cell cycle. We have developed an approach based on the inducible recruitment ...[more]