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Pharmacogenomic agreement between two cancer cell line data sets.

ABSTRACT: Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.

SUBMITTER: Cancer Cell Line Encyclopedia Consortium

PROVIDER: S-EPMC6343827 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Pharmacogenomic agreement between two cancer cell line data sets.

Nature 20151116 7580

Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases. ...[more]

PMID: 26570998

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