Ontology highlight
ABSTRACT:
SUBMITTER: Dempster JM
PROVIDER: S-EPMC6925302 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Dempster Joshua M JM Pacini Clare C Pantel Sasha S Behan Fiona M FM Green Thomas T Krill-Burger John J Beaver Charlotte M CM Younger Scott T ST Zhivich Victor V Najgebauer Hanna H Allen Felicity F Gonçalves Emanuel E Shepherd Rebecca R Doench John G JG Yusa Kosuke K Vazquez Francisca F Parts Leopold L Boehm Jesse S JS Golub Todd R TR Hahn William C WC Root David E DE Garnett Mathew J MJ Tsherniak Aviad A Iorio Francesco F
Nature communications 20191220 1
Genome-scale CRISPR-Cas9 viability screens performed in cancer cell lines provide a systematic approach to identify cancer dependencies and new therapeutic targets. As multiple large-scale screens become available, a formal assessment of the reproducibility of these experiments becomes necessary. We analyze data from recently published pan-cancer CRISPR-Cas9 screens performed at the Broad and Sanger Institutes. Despite significant differences in experimental protocols and reagents, we find that ...[more]