Ontology highlight
ABSTRACT:
SUBMITTER: Erwig MS
PROVIDER: S-EPMC6344079 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Erwig Michelle S MS Patzig Julia J Steyer Anna M AM Dibaj Payam P Heilmann Mareike M Heilmann Ingo I Jung Ramona B RB Kusch Kathrin K Möbius Wiebke W Jahn Olaf O Nave Klaus-Armin KA Werner Hauke B HB
eLife 20190123
Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified the assembly of septin filaments in the innermost non-compacted myelin layer as one of the latest steps of myelin maturation in the central nervous system (CNS) (Patzig et al., 2016). Here we show that loss of the cytoskeletal adaptor protein an ...[more]