Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande V
PROVIDER: S-EPMC6344493 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Deshpande Viraj V Luebeck Jens J Nguyen Nam-Phuong D ND Bakhtiari Mehrdad M Turner Kristen M KM Schwab Richard R Carter Hannah H Mischel Paul S PS Bafna Vineet V
Nature communications 20190123 1
Focal oncogene amplification and rearrangements drive tumor growth and evolution in multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine structure of focally amplified regions using whole genome sequencing (WGS) and validate it extensively on multiple simulated and real datasets, across a wide range of coverage and copy numbers. Analysis of AA-reconstructed amplicons in a pan-cancer dataset reveals many novel properties of copy number amplifications in cancer. ...[more]