Ontology highlight
ABSTRACT:
SUBMITTER: Gellon L
PROVIDER: S-EPMC6344861 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Gellon Lionel L Kaushal Simran S Cebrián Jorge J Lahiri Mayurika M Mirkin Sergei M SM Freudenreich Catherine H CH
Nucleic acids research 20190101 2
Fork stabilization at DNA impediments is key to maintaining replication fork integrity and preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the replication fork. In addition to a structural role, Mrc1 has a DNA damage checkpoint function. Using a yeast model system, we analyzed the role of Mrc1 and Tof1 at expanded CAG repeats of medium and long lengths, which are known to stall replication forks and cause trinucleotide expansion diseases such as Huntington' ...[more]