Dataset Information

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

ABSTRACT:

Background

Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

Methods

We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant.

Results

Of 1343 unique studies, 87 met inclusion criteria, representing 6712 pregnancies in 4174 kidney transplant recipients. Mean maternal age was 29.6?±?2.4?years. The live-birth rate was 72.9% (95% CI, 70.0-75.6). The rate of other pregnancy outcomes was as follows: induced abortions (12.4%; 95% CI, 10.4-14.7), miscarriages (15.4%; 95% CI, 13.8-17.2), stillbirths (5.1%; 95% CI, 4.0-6.5), ectopic pregnancies (2.4%; 95% CI, 1.5-3.7), preeclampsia (21.5%; 95% CI, 18.5-24.9), gestational diabetes (5.7%; 95% CI, 3.7-8.9), pregnancy induced hypertension (24.1%; 95% CI, 18.1-31.5), cesarean section (62.6, 95% CI 57.6-67.3), and preterm delivery was 43.1% (95% CI, 38.7-47.6). Mean gestational age was 34.9?weeks, and mean birth weight was 2470?g. The 2-3-year interval following kidney transplant had higher neonatal mortality, and lower rates of live births as compared to >?3?year, and??35?years as compared to women aged 25-34?years.

Conclusion

Although the outcome of live births is favorable, the risks of maternal and fetal complications are high in kidney transplant recipients and should be considered in patient counseling and clinical decision making.

SUBMITTER: Shah S

PROVIDER: S-EPMC6345071 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

Shah Silvi S Venkatesan Renganathan Lalgudi RL Gupta Ayank A Sanghavi Maitrik K MK Welge Jeffrey J Johansen Richard R Kean Emily B EB Kaur Taranpreet T Gupta Anu A Grant Tiffany J TJ Verma Prasoon P

BMC nephrology 20190123 1

<h4>Background</h4>Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.<h4>Methods</h4>We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant.<h4>Results</h4>O ...[more]

PMID: 30674290

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Dataset Information

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

Background

Methods

Results

Conclusion

Publications

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

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