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Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis.


ABSTRACT: Probiotics are living microorganisms that, when administered in adequate amounts, confer a health benefit. It has been speculated that probiotics might help prevent preterm birth, but in two previous systematic reviews possible major increases in this risk have been suggested. Our objective was to perform a systematic review and meta-analysis of the risk of preterm birth and other adverse pregnancy outcomes in pregnant women taking probiotics, prebiotics or synbiotics.We searched six electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Web of Science's Core collection and BIOSIS Preview) up to September 2016 and contacted authors for additional data. We included randomized controlled trials in which women with a singleton pregnancy received a probiotic, prebiotic or synbiotic intervention. Two independent reviewers extracted data using a piloted form and assessed the risk of bias using the Cochrane risk of bias tool. We used random-effects meta-analyses to pool the results.We identified 2574 publications, screened 1449 non-duplicate titles and abstracts and read 160 full text articles. The 49 publications that met our inclusion criteria represented 27 studies. No study used synbiotics, one used prebiotics and the rest used probiotics. Being randomized to take probiotics during pregnancy neither increased nor decreased the risk of preterm birth

SUBMITTER: Jarde A 

PROVIDER: S-EPMC5759212 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis.

Jarde Alexander A   Lewis-Mikhael Anne-Mary AM   Moayyedi Paul P   Stearns Jennifer C JC   Collins Stephen M SM   Beyene Joseph J   McDonald Sarah D SD  

BMC pregnancy and childbirth 20180108 1


<h4>Background</h4>Probiotics are living microorganisms that, when administered in adequate amounts, confer a health benefit. It has been speculated that probiotics might help prevent preterm birth, but in two previous systematic reviews possible major increases in this risk have been suggested. Our objective was to perform a systematic review and meta-analysis of the risk of preterm birth and other adverse pregnancy outcomes in pregnant women taking probiotics, prebiotics or synbiotics.<h4>Meth  ...[more]

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