Ontology highlight
ABSTRACT:
SUBMITTER: Hariono M
PROVIDER: S-EPMC6345492 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hariono Maywan M Choi Sy Bing SB Roslim Ros Fatihah RF Nawi Mohamed Sufian MS Tan Mei Lan ML Kamarulzaman Ezatul Ezleen EE Mohamed Nornisah N Yusof Rohana R Othman Shatrah S Abd Rahman Noorsaadah N Othman Rozana R Wahab Habibah A HA
PloS one 20190124 1
Dengue virus Type 2 (DENV-2) is predominant serotype causing major dengue epidemics. There are a number of studies carried out to find its effective antiviral, however to date, there is still no molecule either from peptide or small molecules released as a drug. The present study aims to identify small molecules inhibitor from National Cancer Institute database through virtual screening. One of the hits, D0713 (IC50 = 62 μM) bearing thioguanine scaffold was derivatised into 21 compounds and eval ...[more]