Ontology highlight
ABSTRACT:
SUBMITTER: Mills KA
PROVIDER: S-EPMC6345644 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Mills Kathryn A KA Roach S Tanner ST Quinn Jeanne M JM Guo Lei L Beck Hollie M HM Lomonosova Elena E Ilivicky Anna R AR Starks Courtney M CM Lawrence Julie A JA Hagemann Andrea R AR McCourt Carolyn C Thaker Premal H PH Powell Matthew A MA Mutch David G DG Fuh Katherine C KC
Gynecologic oncology 20180903 2
<h4>Objective</h4>Paclitaxel, a microtubule inhibitor, is subject to tumor resistance while treating high-grade serous ovarian and uterine cancer. This study aims to directly compare the effects of SQ1274, a novel microtubule inhibitor that binds to the colchicine-binding site on tubulin, and paclitaxel in high-grade serous ovarian and uterine cancer cell lines both in vitro and in vivo.<h4>Methods</h4>We assessed the sensitivity of ovarian (OVCAR8) and uterine (ARK1) cancer cell lines to SQ1274 ...[more]