Ontology highlight
ABSTRACT:
SUBMITTER: Reddy KC
PROVIDER: S-EPMC6347328 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Reddy Kirthi C KC Dror Tal T Underwood Ryan S RS Osman Guled A GA Elder Corrina R CR Desjardins Christopher A CA Cuomo Christina A CA Barkoulas Michalis M Troemel Emily R ER
PLoS pathogens 20190114 1
Immune genes are under intense, pathogen-induced pressure, which causes these genes to diversify over evolutionary time and become species-specific. Through a forward genetic screen we recently described a C. elegans-specific gene called pals-22 to be a repressor of "Intracellular Pathogen Response" or IPR genes. Here we describe pals-25, which, like pals-22, is a species-specific gene of unknown biochemical function. We identified pals-25 in a screen for suppression of pals-22 mutant phenotypes ...[more]