Ontology highlight
ABSTRACT:
SUBMITTER: Phillips CB
PROVIDER: S-EPMC6347451 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Phillips Charles B CB Tsai Chen-Wei CW Tsai Ming-Feng MF
eLife 20190115
The mitochondrial calcium uniporter is a Ca<sup>2+</sup> channel that regulates intracellular Ca<sup>2+</sup> signaling, oxidative phosphorylation, and apoptosis. It contains the pore-forming MCU protein, which possesses a DIME sequence thought to form a Ca<sup>2+</sup> selectivity filter, and also regulatory EMRE, MICU1, and MICU2 subunits. To properly carry out physiological functions, the uniporter must stay closed in resting conditions, becoming open only when stimulated by intracellular Ca< ...[more]