Ontology highlight
ABSTRACT:
SUBMITTER: Emmett MJ
PROVIDER: S-EPMC6347506 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature reviews. Molecular cell biology 20190201 2
Cell-type-specific gene expression is physiologically modulated by the binding of transcription factors to genomic enhancer sequences, to which chromatin modifiers such as histone deacetylases (HDACs) are recruited. Drugs that inhibit HDACs are in clinical use but lack specificity. HDAC3 is a stoichiometric component of nuclear receptor co-repressor complexes whose enzymatic activity depends on this interaction. HDAC3 is required for many aspects of mammalian development and physiology, for exam ...[more]