Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6347691 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Wang Xing X Zhang Yifei Y Blair Seth S SS
Proceedings of the National Academy of Sciences of the United States of America 20190103 4
The <i>Drosophila</i> protocadherin Fat controls organ size through the Hippo pathway, but the biochemical links to the Hippo pathway components are still poorly defined. We previously identified Dlish, an SH3 domain protein that physically interacts with Fat and the type XX myosin Dachs, and showed that Fat's regulation of Dlish levels and activity helps limit Dachs-mediated inhibition of Hippo pathway activity. We here characterize a parallel growth control pathway downstream of Fat and Dlish. ...[more]