Ontology highlight
ABSTRACT:
SUBMITTER: Chen BB
PROVIDER: S-EPMC3631463 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Chen Bill B BB Coon Tiffany A TA Glasser Jennifer R JR McVerry Bryan J BJ Zhao Jing J Zhao Yutong Y Zou Chunbin C Ellis Bryon B Sciurba Frank C FC Zhang Yingze Y Mallampalli Rama K RK
Nature immunology 20130331 5
Uncontrolled activation of tumor necrosis factor receptor-associated factor (TRAF) proteins may result in profound tissue injury by linking surface signals to cytokine release. Here we show that a ubiquitin E3 ligase component, Fbxo3, potently stimulates cytokine secretion from human inflammatory cells by destabilizing a sentinel TRAF inhibitor, Fbxl2. Fbxo3 and TRAF protein in circulation positively correlated with cytokine responses in subjects with sepsis, and we identified a polymorphism in ...[more]