Ontology highlight
ABSTRACT:
SUBMITTER: Spetea M
PROVIDER: S-EPMC6348443 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Spetea Mariana M Rief Silvia B SB Haddou Tanila Ben TB Fink Monika M Kristeva Elka E Mittendorfer Harald H Haas Stefanie S Hummer Nora N Follia Valeria V Guerrieri Elena E Asim Muhammad Faheem MF Sturm Sonja S Schmidhammer Helmut H
Journal of medicinal chemistry 20190103 2
Herein, the synthesis and pharmacological characterization of an extended library of differently substituted N-methyl-14- O-methylmorphinans with natural and unnatural amino acids and three dipeptides at position 6 that emerged as potent μ/δ opioid receptor (MOR/DOR) agonists with peripheral antinociceptive efficacy is reported. The current study adds significant value to our initial structure-activity relationships on a series of zwitterionic analogues of 1 (14- O-methyloxymorphone) by targetin ...[more]