Ontology highlight
ABSTRACT:
SUBMITTER: Ohui K
PROVIDER: S-EPMC6348444 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Ohui Kateryna K Afanasenko Eleonora E Bacher Felix F Ting Rachel Lim Xue RLX Zafar Ayesha A Blanco-Cabra Núria N Torrents Eduard E Dömötör Orsolya O May Nóra V NV Darvasiova Denisa D Enyedy Éva A ÉA Popović-Bijelić Ana A Reynisson Jóhannes J Rapta Peter P Babak Maria V MV Pastorin Giorgia G Arion Vladimir B VB
Journal of medicinal chemistry 20181218 2
Six morpholine-(iso)thiosemicarbazone hybrids HL<sup>1</sup>-HL<sup>6</sup> and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Cu(II) complexes [Cu(L<sup>1-6</sup>)Cl] (1-6) formed weak dimeric associates in the solid state, which did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu(II) complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition, complexes 2-5 ...[more]