Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC6514978 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Liu Lili L Shao Liping L Li Jing J Cui Haifeng H Li Bing B Zhou Xuzheng X Lv Pengyue P Zhang Jiyu J
Molecules (Basel, Switzerland) 20190425 8
To combat bacterial resistance, a series of new oxazolidinone-fluoroquinolone hybrids have been synthesized and characterized. All synthetic hybrids were preliminarily evaluated for their in vitro antibacterial activities against 6 standard strains and 3 clinical isolates. The majority of hybrids displayed excellent activities against Gram-positive bacteria, but limited activities against Gram-negative bacteria. Hybrids OBP-4 and OBP-5 were found to be the most promising compounds. Further, in v ...[more]