Ontology highlight
ABSTRACT:
SUBMITTER: Pillman KA
PROVIDER: S-EPMC6348984 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Pillman Katherine A KA Goodall Gregory J GJ Bracken Cameron P CP Gantier Michael P MP
RNA (New York, N.Y.) 20181128 2
Most microRNAs (miRNAs) are expressed as a mix of length isoforms (referred to as isomiRs). IsomiR stoichiometry can be differentially impacted upon cell stimulation, as recently evidenced by our group in the context of immune responses induced by type-I interferon (IFN). Here, we revisit published RNA-seq data sets of human and mouse macrophages stimulated with bacterial products at the isomiR level. We demonstrate that for several miRNAs, macrophage stimulation induces changes in isomiR stoich ...[more]