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Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging.


ABSTRACT: Near-infrared II fluorescence imaging holds great promise for in vivo imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which largely hinders their biomedical application in vivo. In this study, the first NIR-II organic aggregation-induced emission (AIE) fluorophore (HLZ-BTED), encapsulated as nanoparticles (HLZ-BTED dots) for in vivo biomedical imaging, was designed and synthesized. The NIR-II AIE HLZ-BTED dots showed high temporal resolution, high photostability, outstanding water-solubility and biocompatibility in vitro and in vivo. The HLZ-BTED dots were further used for long-term breast tumor imaging and visualizing tumor-feeding blood vessels, long-term hind limb vasculature and incomplete hind limb ischemia. More importantly, as a proof-of-concept, this is the first time that non-invasive and real-time NIR-II imaging of the gastrointestinal tract in health and disease has been performed, making the AIE dots a promising tool for gastrointestinal (GI) tract research, such as understanding the healthy status of GI peristalsis, diagnosing and evaluating intestinal motility dysfunction, and assessing drug effects on intestinal obstruction.

SUBMITTER: Lin J 

PROVIDER: S-EPMC6349025 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Novel near-infrared II aggregation-induced emission dots for <i>in vivo</i> bioimaging.

Lin Jiacheng J   Zeng Xiaodong X   Xiao Yuling Y   Tang Lin L   Nong Jinxia J   Liu Yufang Y   Zhou Hui H   Ding Bingbing B   Xu Fuchun F   Tong Hanxing H   Deng Zixin Z   Hong Xuechuan X  

Chemical science 20181109 4


Near-infrared II fluorescence imaging holds great promise for <i>in vivo</i> imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which largely hinders their biomedical application <i>in vivo</i>. In this study, the first NIR-II organic aggregation-induced emission (AIE) fluorophore (<b>HLZ-BTED</b>), encapsulated as nanop  ...[more]

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