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Near-Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots.

ABSTRACT: Recently, upconversion luminescence (UCL) has been widely applied in bioimaging due to its low autofluorescence and high contrast. However, a relatively high power density is still needed in conventional UCL bioimaging. In the present study, an ultralow power density light, as low as 0.06 mW cm-2, is applied as an excitation source for UCL bioimaging with PbS/CdS/ZnS quantum dots (UCL-QDs) as probes. The speculated UCL mechanism is a phonon-assisted single-photon process, and the relative quantum yield is up to 4.6%. As determined by continuous irradiation with a 980 nm laser, the UCL-QDs show excellent photostability. Furthermore, UCL-QDs-based probe is applied in tumor, blood vessel, and lymph node bioimaging excited with an eye-safe low-power light-emitting diode light in a nude mouse with few heat effects.

SUBMITTER: Qiu X

PROVIDER: S-EPMC6402406 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Near-Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots.

Qiu Xiaochen X Zhu Xingjun X Su Xianlong X Xu Ming M Yuan Wei W Liu Qingyun Q Xue Meng M Liu Yawei Y Feng Wei W Li Fuyou F

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190118 5

Recently, upconversion luminescence (UCL) has been widely applied in bioimaging due to its low autofluorescence and high contrast. However, a relatively high power density is still needed in conventional UCL bioimaging. In the present study, an ultralow power density light, as low as 0.06 mW cm-2, is applied as an excitation source for UCL bioimaging with PbS/CdS/ZnS quantum dots (UCL-QDs) as probes. The speculated UCL mechanism is a phonon-assisted single-photon process, and the rela ...[more]

PMID: 30886806

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