Ontology highlight
ABSTRACT:
SUBMITTER: Ueda Y
PROVIDER: S-EPMC6349056 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chemical science 20181126 4
We developed a non-toxic cyanation reaction of various aryl halides and triflates in acetonitrile using a catalyst system of [Ni(MeCN)<sub>6</sub>](BF<sub>4</sub>)<sub>2</sub>, 1,10-phenanthroline, and 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine (<i>Si</i>-Me<sub>4</sub>-DHP). <i>Si</i>-Me<sub>4</sub>-DHP was found to function as a reductant for generating nickel(0) species and a silylation reagent to achieve the catalytic cyanation <i>via</i> C-CN bond cleavage. ...[more]