Ontology highlight
ABSTRACT:
SUBMITTER: Zysnarski CJ
PROVIDER: S-EPMC6349100 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zysnarski Christopher J CJ Lahiri Sagar S Javed Fatima T FT Martínez-Márquez Jorge Y JY Trowbridge Justin W JW Duncan Mara C MC
The Journal of biological chemistry 20181206 4
Cellular membrane trafficking mediated by the clathrin adaptor protein complex-1 (AP-1) is important for the proper composition and function of organelles of the endolysosomal system. Normal AP-1 function requires proteins of the HEAT repeat-containing 5 (HEATR5) family. Although HEATR5 proteins were first identified based on their ability to interact with AP-1, the functional significance of this interaction was unknown. We used bioinformatics-based phenotypic profiling and information from gen ...[more]