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Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model.

ABSTRACT: Phthalocyanines (Pc) and their metallated derivatives are strongly considered for photodynamic therapy (PDT) possessing unique properties as possible new photosensitizers (PS). We have used toxicological assessments, real-time monitoring of cellular impedance, and imagistic measurements for assessing the in vitro dark toxicity and PDT efficacy of Ga(III)-Pc in SHSy5Y neuroblastoma cells. We have established the non-toxic concentration range of Ga(III)-Pc, a compound which shows a high intracellular accumulation, with perinuclear distribution in confocal microscopy. By choosing Ga(III)Pc non-toxic dose, we performed in vitro experimental PDT hampering cellular proliferation. Our proposed Ga(III)-Pc could complete a future PS panel for neuroblastoma alternate therapy.

SUBMITTER: Constantin C

PROVIDER: S-EPMC6349146 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model.

Constantin Carolina C Lupu Andreea-Roxana AR Fertig Tudor Emanuel TE Gherghiceanu Mihaela M Pop Sevinci S Ion Rodica-Mariana RM Neagu Monica M

Journal of cellular and molecular medicine 20181119 2

Phthalocyanines (Pc) and their metallated derivatives are strongly considered for photodynamic therapy (PDT) possessing unique properties as possible new photosensitizers (PS). We have used toxicological assessments, real-time monitoring of cellular impedance, and imagistic measurements for assessing the in vitro dark toxicity and PDT efficacy of Ga(III)-Pc in SHSy5Y neuroblastoma cells. We have established the non-toxic concentration range of Ga(III)-Pc, a compound which shows a high intracellu ...[more]

PMID: 30451363

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| S-EPMC5342510 | biostudies-literature

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| S-EPMC9812264 | biostudies-literature

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