Ontology highlight
ABSTRACT:
SUBMITTER: Guan Y
PROVIDER: S-EPMC6349201 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Guan Yi Y Gao Xueting X Tang Qiuyu Q Huang Lin L Gao Siyun S Yu Shuai S Huang Jiale J Li Jun J Zhou Daizhan D Zhang Yangyang Y Shi Dan D Liang Dandan D Liu Yi Y Li Li L Cui Yingyu Y Xu Liang L Chen Yi-Han YH
Journal of cellular and molecular medicine 20181203 2
Nucleoporins (Nups) are known to be functional in nucleo-cytoplasmic transport, but the roles of nucleoporins in nonproliferating cells, such as cardiac myocytes, are still poorly understood. In this study, we report that Nup107 regulates cardiac bioelectricity by controlling the nucleo-cytoplasmic trafficking of Scn5a mRNA. Overexpression of Nup107 induced the protein expression of Scn5a rather than that of other ion channels, with no effects of their mRNA levels. The analysis for the protein p ...[more]