Ontology highlight
ABSTRACT:
SUBMITTER: Downie Ruiz Velasco A
PROVIDER: S-EPMC6350214 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Downie Ruiz Velasco Angela A Welten Sabine M J SMJ Goossens Eveline A C EAC Quax Paul H A PHA Rappsilber Juri J Michlewski Gracjan G Nossent A Yaël AY
Molecular therapy. Nucleic acids 20181206
After induction of ischemia in mice, 14q32 microRNAs are regulated in three distinct temporal patterns. These expression patterns, as well as basal expression levels, are independent of the microRNA genes' order in the 14q32 locus. This implies that posttranscriptional processing is a major determinant of 14q32 microRNA expression. Therefore, we hypothesized that RNA binding proteins (RBPs) regulate posttranscriptional processing of 14q32, and we aimed to identify these RBPs. To identify protein ...[more]